Chronic Leukaemias & Myeloproliferative Disorders

1.Define and classify myeloproliferative neoplasms. Discuss the clinical features and laboratory diagnosis of chronic myeloid leukaemia

2.A 60-year-old male develops fatiguability, weakness, weight loss and a dragging sensation in the abdomen. Blood examination reveals a total count exceeding 100,000 cells /cu mm. O/E massive splenomegaly.

• a) What is your provisional diagnosis.
• b) Describe the peripheral smear and bone marrow findings.
• c) Describe the pathogenesis and the further tests to be done

1.Philadelphia chromosome

2.A 60 year old male patient was brought to the hospital with history of weakness and lethargy since 6 months. On examination he had mild pallor and massive splenomegaly extending up to the umbilicus. He had no palpable lymph nodes. Lab reports showed a total WBC count of 1.5 lakh cells/ mm3.

• a) What is your diagnosis
• b) Discuss the lab diagnosis of this condition
• c) Name the molecular test that you would do to confirm your diagnosis

3.Myelodysplastic syndrome

4.A 50 years old male presented with weakness, pallor and massive splenomegaly. Blood examination revealed marked increase in the total count. Answer the following:

• a) What is the probable diagnosis.
• b) What are the peripheral smear findings.
• c) What is the genetic abnormality.
• d) What are the different stages of disease progression

5.45 years old male presented with splenomegaly and anemia. His total WBC count was 1.5 lakhs per cu mm with myeloid precursors of all series in peripheral blood. Answer the following:

• a) What is your diagnosis.
• b) Describe the peripheral blood and bone marrow findings.
• c) What is the cytogenetic abnormality

6.A 53 year old male presented with pain abdomen. Investigations: Hb 8g/dl TC 70,000/cmm DC N 55 L 10 myelocyte 15 metamyelo 10 band 1 eosino 6 baso 3 platelet count 5.8 lakh/cmm. Answer the following:

• a) What is your diagnosis.
• b) Describe the peripheral blood picture and bone marrow findings in this condition
• c) Name the cytogenetic abnormality associated

1.Laboratory Findings in Chronic myeloid leukemia

2.Peripheral smear findings in chronic lymphocytic leukemia

1.Write the chromosomal abnormality in Chronic myeloid leukemia

2.What is the cytogenetic abnormality seen in Chronic Myeloid Leukemia