Glomerular Disease

1.What are the manifestations of nephritic syndrome. Discuss the light microscopic findings in post streptococcal glomerulonephritis. Add a note on the findings on immunofluorescence

2.A 10-year-old female presented with sudden onset of hematuria and oliguria. Urine examination shows presence of RBC, casts and mild proteinuria.

• a) What is your probable diagnosis
• b) Discuss etiopathogenesis and classification of the disease
• c) Mention the morphological features of the target organ
• d) Laboratory diagnosis of the disease

3.A 7-year-old boy presents with puffiness of eyelids, decreased urine output of 6 days duration. Clinical examination reveals generalized edema and mild hypertension. Urine examination reveals numerous RBCs and mild proteinuria. He gives a history of a sore throat 3 weeks ago. A renal biopsy is performed.

• a) What is your provisional diagnosis
• b) Describe the pathogenesis of this condition
• c) What features do you expect to see in the renal biopsy
• d) What is the outcome of this disease

4.Discuss in detail the etiology and pathogenesis of post streptococcal glomerulonephritis. Add a note on morphology of kidney in post streptococcal glomerulonephritis

1.Renal lesions in Diabetes Mellitus

2.A 10 year old boy presented with oliguria, hematuria and hypertension. He gave a past history of sore throat two weeks back.

• a) What is the most probable diagnosis
• b) Discuss the etiopathogenesis of this condition
• c) Add a note on urinary findings

3.Two causes for nephrotic syndrome

4.Gross and microscopic changes in kidney in a long standing case of Diabetes Mellitus

5.Diabetic microangiopathy

6.Diabetic nephropathy

7.Causes of heavy proteinuria

8.A 5 years old boy was admitted with history of oliguria, facial edema and dark colored urine. His BP was 140/100 mm of Hg. Answer the following:

• a) What is your provisional diagnosis.
• b) What are the laboratory findings in urine examination in this patient
• c) How do you examine urinary sediments and describe the sediments seen in urine

1.Renal changes in Diabetes mellitus

2.Crescentic glomerulo nephritis

3.Define nephrotic syndrome. Describe the gross and microscopic changes in kidney in Systemic Lupus Erythematosus

4.Discuss the etiopathogenesis and urinary findings in poststreptococcal glomerulonephritis

5.Nephrotic range proteinuria – Definition and common causes

6.Etiology and morphology of chronic glomerulonephritis

7.Glomerular lesions in diabetic nephropathy

8.Acute glomerulonephritis

1.Name the histological features in post infectious glomerulonephritis

2.Name two causes of flea bitten kidney

1.A 6 year old school going boy was brought by his father to the Paediatric OPD with complaints of swelling in the face and leg for the past one week with passing of reduced amount of high coloured urine since 3 days. The father also gave a past history of the boy having scabies, detected and treated in his school health programme. On examination the boy is under nourished, periorbital edema present, pedal edema present. His Blood pressure was 130/100 mm of Hg.Pulse rate was 94/mt regular

• a) What is your provisional diagnosis
• b) Aetiopathogenesis of this condition
• c) List the investigations and their interpretations to support your diagnosis
• d) What is the prognosis of this condition

2.Thickening of the basement membrane 2) Nodular Glomerulosclerosis

• 3) Diffuse Glomerulosclerosis 4) Armani Epstein lesion
• a) 1, 2 and 3 are correct
• b) 2, 3 and 4 are correct
• c) 1, 3 and 4 are correct
• d) 1, 2 and 4 are correct

3.(A): Rotheras test detects proteins in urine

• (R): Nephrotic syndrome causes massive proteinuria
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

4.Hyperplastic arteriosclerosis and fibrinoid necrosis are associated with

• a) Membranoproliferative glomerulonephritis
• b) Analgesic abuse
• c) Malignant hypertension
• d) Diabetes mellitus