Coagulation Disorders

1.Haemophilia A

2.Pathogenesis and lab diagnosis of Disseminated intravascular coagulation

3.Pictorially describe the extrinsic and intrinsic pathway of coagulation. Mention the tests used in their assessment with their normal ranges

4.A 15 years old boy was admitted for severe hemorrhage after trauma. On examination he had haemarthrosis of large joints and muscle hematomas. Some of the family members have similar clinical manifestations. Answer the following:

• a) What is the provisional diagnosis.
• b) Which are the four lab investigations to be done to confirm the diagnosis. Explain the changes in these investigations expected in this patient
• c) What is the pathogenesis of this disease

5.List two hematological evidences of DIC

1.Hemophilia

2.Lab diagnosis of Hemophilia A

1.(A): von Willebrand factor is synthesized by Hepatocytes

• (R): von Willebrand factor is a carrier protein for factor VIII
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.Fibrin degradation products have

• a) Potent anticoagulant effect
• b) Platelet aggregation effect
• c) Prothrombotic effect
• d) Endothelial activation effect

3.What is your most probable clinical diagnosis

• a) Acute Leukaemia
• b) Immune thrombocytopenia
• c) Disseminated Intravascular coagulation
• d) Anaphylactic shock

4.Which one of the following investigation is diagnostic

• a) Platelet Count
• b) Prothrombin time
• c) Thrombin Time
• d) D – dimer test