Carcinogenesis & Oncogenes

1.(a) Define neoplasia.

• a) Enumerate the four classes of normal regulatory genes, with one example each, that are the principal targets of genetic damage leading to carcinogenesis.
• b) Write a note on how viruses are implicated in carcinogenesis with examples.
• c) Tabulate the salient differences between benign and malignant tumors

1.Define neoplasia. Discuss chemical carcinogenesis

2.Role of Chemical Carcinogens

3.Oncogenic DNA viruses

4.Microbial carcinogenesis

5.Name an oncogenic virus and the tumour caused by it

6.Proto oncogene

7.Mention two tumor suppressor genes

8.Stem cell

9.List two tumors caused by Epstein-Barr-virus

10.Name four carcinogenic viruses

11.Epstein bar virus induced tumors in humans

1.Role of P53 in gene in tumor suppression

2.Discuss chemical carcinogenesis with examples

3.Viral oncogenes

4.Radiation and cancer

5.Oncogenes

1.Name two oncogenic viruses and the malignancy they cause

1.Epstein Barr Virus is associated with the following cancers

• 1) Endometrial Carcinoma 2) Nasopharyngeal Carcinoma
• 3) Gastric carcinoma 4) Hodgkin’s Lymphoma
• a) 1, 2 and 3 are correct
• b) 2, 3 and 4 are correct
• c) 1, 3 and 4 are correct
• d) 1, 2 and 4 are correct

2.(A): More than 70% of human cancers have a defect in p53 gene

• (R): p53 plays a central role in maintaining the integrity of the genome
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

3.N-myc is a

• a) Signal transduction factor
• b) Growth factor
• c) Growth factor receptor
• d) Nuclear transcription factor