Intestinal Pathology

1.Differences between Crohn disease and Ulcerative colitis

2.Classification of intestinal polyps

3.Intestinal polyps: classification and syndromes

4.Discuss the types of ulcers in intestine (large and small intestine)

5.Discuss the etiopathogenesis of carcinoma colon with a note on the adenoma- carcinoma sequence

6.A 65-year old male presented with change in bowel habits, loss of weight, loss of appetite, weakness, and malaise since one year. After an endoscopic biopsy of the colon, left hemicolectomy was done. Answer the following.

• a) What is the clinical diagnosis.
• b) Describe the etiology and morphology of the lesion.
• c) Molecular mechanism

7.Precancerous lesion of intestine

8.A 72 years old male presented with changes in the bowel habit, bleeding per rectum, loss of weight, fatigue and weakness of six months duration. After endoscopic biopsy of colon, a left sided hemicolectomy was done. Answer the following:

• a) What is the probable diagnosis.
• b) Describe the etiopathogenesis.
• c) Describe the gross and microscopic features of the resected colon
• d) Mention the serological marker which is increased

9.Gross and microscopy of ulcerative colitis

1.Compare and contrast four important microscopic features of Crohn’s disease and Ulcerative Colitis

2.Differentiate between ulcerative colitis and crohn’s disease

3.Aetiopathogenesis of carcinoma colon

4.Morphology of ulcerative colitis

5.Polyps of intestine

6.Inflammatory bowel disease

7.Microscopic features to distinguish Crohn disease from ulcerative colitis

8.Morphology of Crohns disease

9.Etiopathogenesis of ulcerative colitis

1.Name the common molecular abnormality in carcinoma colon

2.What is Peutz Jegher’s polyp

1.(A) Prophylactic colectomy is to be done in all patients with Familial Adenomatous Polyposis (FAP) (R) Minimum 100 polyps are necessary for the diagnosis of FAP

• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.Risk factors of colorectal adenocarcinoma includes

• 1) Familial adenomatous polyp 2) Obesity
• 3) Low fiber diet 4) Intestinal amoebiasis
• a) 1, 2, 3
• b) 2, 3, 4
• c) 3, 4, 1
• d) 1, 2, 4