Anaemia

1.40 years old alcoholic vegetarian comes to out- patient department with history of fatigue, weakness and exertional breathlessness. On examination patient is anemic with red beefy tongue and knuckle pigmentation. Answer the following

• a) What is your likely diagnosis and cause for knuckle pigmentation.
• b) What are the likely causes and mechanism of this condition.
• c) How will you investigate this patient.
• d) How do you manage this patient

2.A 65 years old woman comes with general malaise, tiredness since six months and two months history of shortness of breath on moderate exertion. She c/o, sore tongue, pins and needles sensation in her feet. Her blood smear shows macrocytic anemia and thrombocytopenia. Answer the following

• a) What are your differential diagnosis
• b) What further investigations you do.
• c) Describe the peripheral and bone marrow picture of megaloblastic anemia.
• d) How do you treat

1.Megaloblastic anemia

2.Treatment of vitamin B12 deficiency

3.Differential diagnosis of microcytic anemia

4.Treatment of G6PD deficiency

5.Clinical triad of hemolytic anaemia

6.Drug induced causes of macrocytic anemia

7.Laboratory tests of Iron deficiency anaemia

8.Causes of anaemia in CKD

9.Causes of methaemoglobinemia

10.Causes of pancytopenia

11.Importance of prenatal screening and counselling in thalassemias

12.Iron chelation therapy

13.Genetics of thalassemia

14.Complications of homocysteinemia

15.Treatment of iron deficiency anemia

1.Assertion (A): B12 deficiency is the most common reason for Megaloblastic anaemia Reason(R): B12 deficiency is the reason for Hyper segmented Neutrophils

• a) Both A and R are true and R is the
• b) Both A and R are true but R is not the correct explanation of A
• c) A is true but R is false
• d) A is false but R is

2.Which of the following are the most likely cause of non megaloblastic macrocytic anaemia (select two)

• 1) Hypothyroidism
• 2) Alcohol abuse
• 3) Thiamine deficiency
• 4) Vitamin B12 deficiency
• a) 1 & 2 are correct
• b) 1 & 3 are correct
• c) 3 & 4 are correct
• d) 2 & 4 are correct