Liver Disease & Hepatology

1.53 year old man Chronic alcoholic brought to emergency room with altered sensorium of one day duration and one episode of seizure. On examination Odema present, deeply Icteric, subconjunctival hemorrhage present, Ascites present

• a) What is your probable Diagnosis
• b) Describe all clinical signs of this condition
• c) How do you investigate this condition
• d) What are the complications
• e) Discuss treatment

2.A 45-year-old man who consumes alcohol regularly presents with altered sensorium and vomiting of blood since the last two days. He has abdominal distension since the last 8 months

• a) What is the probable diagnosis
• b) Write briefly about the pathophysiology of this condition
• c) Enumerate all the clinical signs of this condition
• d) How do you investigate this patient
• e) How do you treat this patient
• f) What are the complications of this condition

3.A 35-year-old male who is a chronic alcoholic presents with yellowish discolouration of eyes, abdominal distension since six months, lower limb swelling since three months, altered sensorium since two days

• a) What is the probable diagnosis and differential diagnosis.
• b) Enumerate all the clinical signs of this condition.
• c) How do you investigate this patient
• d) How do you treat this patient
• e) What are the complications of this condition

4.40 years old female non-alcoholic developed yellowish discoloration of sclera and urine. She developed vomiting and right hypochondrial pain. Answer the following:

• a) What is your probable diagnosis
• b) How will you confirm the diagnosis
• c) How will you treat this condition
• d) How will you prevent this disease

5.A 45 years old man who is a chronic alcoholic presents with the history of tarry black stools and fresh blood vomiting since 2 days. On examination he is ill looking, pale and has tachycardia. He has ascites but no palpable spleen. His blood pressure is 90/60 mm Hg. Answer the following :

• a) What is your likely diagnosis
• b) What steps should be taken immediately in the management
• c) How will you treat this condition
• d) What are the complication of this condition

6.40 year old individual presented with fatigue, weight loss and upper abdominal discomfort. Clinical examination revealed hepatosplenomegaly and ascites. Answer the following:

• a) What other history will you elicit to detect the possible etiology of his disease
• b) What investigations will you do to evaluate his condition
• c) How will you manage this case
• d) What are the complications of this condition

1.Hepatorenal syndrome

1.Hepatitis B infection

1.Newer drugs for hepatitis C

2.Precipitating factors of hepatic encephalopathy

3.Major clinical manifestations of portal hypertension

4.Complications of cirrhosis of liver

5.Hepatitis B infection – serological markers

6.Name two causes for splenomegaly

7.Name two drugs used in chronic hepatitis B infection

8.Clinical features of Budd chiari syndrome

9.Post Exposure prophylaxis in Hepatitis B infection

10.Aetiology of cirrhosis of liver

11.Causes of massive splenomegaly

12.Interpretation of serum albumin plural fluid albumin gradient

13.Interpretation of Serum-Ascites Albumin Gradient (SAAG). Give two causes of ascites with low SAAG

14.Diagnosis of spontaneous bactertial peritonitis

15.Serological markers of chronic hepatitis B infection

1.Assertion: Acute fatty liver of pregnancy is more common in multiparous women.

• Reason: Acute fatty liver is characteristic of a defect in beta oxidation of fatty acid in the mitochondria
• a) Both A and R are true, R is the correct explanation of A
• b) Both A and R are true, R is not the correct explanation of A
• c) A is true but R is false
• d) A is false but R is true